Heat and Cold Intolerance

Temperature sensitivity is common in Fabry disease. It presumably results from lipid deposition in small vessel walls, perineural cells, and unmyelinated or myelinated nerve cells resulting in small fiber neuropathy.1 Hypohidrosis and anhidrosis may also contribute to heat intolerance.


1. Hilz MJ, B Stemper, EH Kolodny. Lower limb cold exposure induces pain and prolonged small fiber dysfunction in Fabry patients. Pain. 2000;84:361-365.